D-Mannose + Cranberry

They work through different mechanisms and complement each other. D-mannose binds directly to E. coli — the bacteria responsible for about 80-90% of UTIs — preventing them from attaching to the bladder wall. Cranberry proanthocyanidins (PACs) work on a separate adhesion pathway, targeting a different bacterial attachment mechanism. D-mannose alone closes one route. Cranberry alone closes another. Together, they block both. The research on D-mannose goes back to randomized controlled trials; the cranberry PAC research has reached the level of a meta-analysis of 10 randomized controlled trials. Both work at the level of prevention, not treatment.*

Three main differences. First, this formula includes 1100mg of D-mannose — which most cranberry supplements don't contain at all. Second, our cranberry extract is standardized to 36% proanthocyanidins (PACs), which is the concentration that aligns with the threshold established in clinical research. Most generic cranberry supplements are not standardized — you don't know how much active PAC you're getting. Third, we've added hibiscus and dandelion root for flush support, and vitamin C to help acidify urine. It's a complete formula that addresses urinary health from four angles, not a single ingredient.

Two capsules, once a day. Most women take it in the morning with water, with or without food. Consistency matters more than timing — D-mannose works best as a daily habit, so pick a time you'll remember and stick with it. If you're using this after finishing antibiotics for a UTI, it's fine to take them alongside your antibiotic course, but let your doctor know what you're taking.

Yes — and it's a natural pairing. The vaginal probiotic supports your vaginal microbiome from the inside. D-Mannose + Cranberry supports your urinary tract through a completely different mechanism. They don't share ingredients and work on different systems. Many women take both as a foundational stack for overall vaginal and urinary health. There's no interaction or overlap to worry about.

This formula is designed for prevention, not treatment. D-mannose may help limit further bacterial adhesion if taken early, but it is not a substitute for medical treatment of an active UTI. If you have symptoms — burning, urgency, pain — see a doctor. This product is for maintaining urinary tract health between infections, not for treating one in progress.*

D-mannose and the other ingredients in this formula are generally very well tolerated. At high doses, D-mannose can cause loose stools in some people — starting with one capsule instead of two for the first few days can help if you're sensitive. Dandelion root has mild diuretic effects, which is intentional — you may notice you urinate more frequently, particularly at first. If you have kidney disease or are on diuretic medications, consult your doctor before use. If you experience anything unusual, reduce your dose or stop use.

If you are pregnant, breastfeeding, or trying to conceive, consult your doctor before starting any new supplement. D-mannose is a naturally occurring sugar, but the appropriate dose during pregnancy has not been established in clinical research. Your doctor can advise based on your specific situation.

Yes. The capsules are vegetable-based, not gelatin. The formula contains no gluten, no animal-derived ingredients, and no artificial fillers. It's also non-GMO. The full ingredient list is on the label and the Certificate of Analysis is published at vitamoon.com.